Yohimbine (Yohimbine) - otherwise known as quebrachine - plant alkaloid with stimulant, aphrodisiac, derived from the plant Yohimbe (Yohimbe). Used by bodybuilders for weight loss, drying the muscles, increase libido. The formula of the substance C21H26O3N2. In its pure form is a colorless crystals with melting point 235-237°C.
the Study of this group of alkaloids was stimulated by finding the active principle of known veterinary drugs, the so-called "Horse pathogen". Yohimbine is the main alkaloid of Yohimbe tree (Pausinystalia johimbe Pierre ex Beille), the family Rubiaceae (Rubiaceae), native to Central Africa, still yohimbine is derived from the bark of South American plants, White quebracho (Aspidosperma quebracho-blanco Schltr.) and Rauwolfia Serpentina (Rauvolfia serpentina Benth. ex Kurz), family Kutrovyh (Apocynaceae). The yohimbe bark contains 0.5—1.5% indole alkaloids series. The main alkaloid is Yohimbine, and the rest of the isomers Yohimbine, aymalitsin, aleukemic, koreanteen, dihydrokainate, Corianton (yohimbin).
Yohimbin began to be used as a remedy for erectile dysfunction and stimulator of male potency. Yohimbine has on the human body expressed simpatoliticescoe and stimulating effect. Due to its ability to inhibit MAO (monoamine oxidase) has an antidepressant effect. Yohimbine has a high affinity for the ALPHA2-adrenergic receptors, moderate affinity for alpha1-adrenergic receptors 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.
Yohimbine has antagonism (blocking) to the alpha1-adrenergic, ALPHA2-adrenoceptor, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2 receptors, and interacts agonistically (excites) with 5-HT1A receptors. The effect of Yohimbine have been investigated in the work of Kenneth Grasing, MD and co-authors, which was carried out to study damage (tolerance) and the pharmacodynamic properties of the substance in a fairly large dose (22 mg).
the experiment involved healthy, young people, studied the effect on mood, heart activity, blood pressure, etc. have Been established good tolerability, rapid rate of absorption and excretion of substances. When used together with fatty foods observed decrease in concentration in the blood. Scientists have shown that even high doses do not lead to the development of side effects, moderately increasing heart rate, respiration, thus lowering blood pressure.
a Significant effect Yohimbine exerted on the psyche, initiating a number of psychoactive effects: agitation, mood improvement, etc. can interfere with sleep: Yohimbine improves the brightness and sleep quality, but only in very small doses, if dose more than 1 mg a sense of anxiety during sleep. Yohimbine is much more effective when taken in the early hours in REM sleep.Useful properties of Yohimbine
Yohimbine has a pronounced lipolytic effect, this property allowed us to obtain Yohimbine particularly popular in sports nutrition. Fat burning effect of Yohimbine proved authoritative research. Additionally, Yohimbine has a stimulating effect on the Central nervous system, improving cognitive function, mental focus, allows you to train longer and harder.
As you know, most fat burners act as stimulants of secretion of adrenaline which in turn stimulates alpha and beta adrenergic receptors. Upon excitation of beta-receptors is the destruction of the fat, and upon excitation of alpha-receptors observed the opposite effect: inhibition of the release of adrenaline and the accumulation of fat in fat depots. By blocking alpha-receptors, Yohimbine allows fat freely destroyed with energy release.
There are additional reasons that dictate the need for blocking ALPHA2-adrenergic receptors. This reduces blood pressure, which often increases the use of fat burners and increase the blood flow in adipose tissue, thereby accelerating transport of fatty acids to the place of destruction.
the Difficulty of getting rid of fat in some places, explained by the large number of ALPHA2-adrenergic receptors so Yohimbine can help aiming to remove fat deposits in the most problematic areas.Method of use: 2-3 capsules 1 to 3 times a day
storage: store At room temperature in a dry, protected from light. Do not store in the fridge!